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Finally, A Corona Virus Thread...


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#221 casino

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Posted Yesterday, 08:59 PM

Boris in hospital. Feck. 



#222 jonnyboy

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Posted Yesterday, 09:38 PM

Crikey. Obviously routine test line is unlikely he's obviously in a bit of bother. Hope he's OK we kind of need him at the moment!  



#223 FLD

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Posted Today, 11:08 AM

I see the protease active site has been crystalographically mapped which gives a small molecule approach to treatment.  There are also several small molecule dockings which look promising.



#224 jonnyboy

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Posted Today, 11:16 AM

Whats that in English Matt? 

 

Serious request! 



#225 FLD

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Posted Today, 03:47 PM

Its part of the mechanism for how the virus replicates in the cell.  Think of it as a key machine on a production line.  The active site is like the control panel.  In essence we have a picture of the control panel we just need to interpret it.  This is one of the ways HIV is treated and why it's no longer so terrible.  The downside is that a crystallographic structure is fixed whereas in reality the active site can move around a little. 

 

Docking (not that sort of docking) is putting in small, drug like, molecules into the active site (via computer)  and seeing how they fit into the site.  Kinda like a 3D jigsaw.  There are a few very good fits that I know of in the public domain so I imagine there's a few others too.  This is very promising for future drugability.

 



#226 casino

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Posted Today, 06:04 PM

Its part of the mechanism for how the virus replicates in the cell.  Think of it as a key machine on a production line.  The active site is like the control panel.  In essence we have a picture of the control panel we just need to interpret it.  This is one of the ways HIV is treated and why it's no longer so terrible.  The downside is that a crystallographic structure is fixed whereas in reality the active site can move around a little. 

 

Docking (not that sort of docking) is putting in small, drug like, molecules into the active site (via computer)  and seeing how they fit into the site.  Kinda like a 3D jigsaw.  There are a few very good fits that I know of in the public domain so I imagine there's a few others too.  This is very promising for future drugability.

This sounds like the beginning of something promising. So if the control panel can be switched off then the Miley Cyrus cant replicate? 



#227 coldel

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Posted Today, 06:11 PM

So what are the time consuming bits of the end to end process of developing a vaccine / cure ? 

 

I presume some short cuts in testing will be used, but that still might be months and months?



#228 jonnyboy

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Posted Today, 06:53 PM

Testing 

 

https://en.wikipedia...er_Laboratories






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